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HRID441859

反应详情

EQUATION

反应方程式

HRID 441859 的结构方程式

REACTANTS

反应物

6
结构：CC(=O)c1ccc(Cl)cc1
HCID7467

1-(4-Chlorophenyl)ethanone

C8H7ClO

结构：NNc1ccccc1
HCID7516

Phenylhydrazine

C6H8N2

结构：CCOC(=O)OCC
HCID7766

Diethyl carbonate

C5H10O3

结构：[H-].[Na+]
HCID24758

Sodium hydride

HNa

结构：CCOC(=O)CC(=O)c1ccc(Cl)cc1
HCID101336

Benzenepropanoic acid, 4-chloro-beta-oxo-, ethyl ester

C11H11ClO3

结构：O=C1CC(c2ccc(Cl)cc2)=NN1c1ccccc1
HCID10286088

未命名化合物

PRODUCTS

生成物

1
结构：O=Cc1c(-c2ccc(Cl)cc2)nn(-c2ccccc2)c1Cl
HCID21418360

5-Chloro-3-(4-chlorophenyl)-1-phenyl-1H-pyrazole-4-carbaldehyde

C16H10Cl2N2O

AUXILIARIES

试剂、催化剂与溶剂

2
结构：CC(=O)O
溶剂HCID176

Acetic Acid

C2H4O2

结构：CCO
溶剂HCID702

Ethanol

C2H6O

PROCEDURE

实验过程

50.8 g of ethyl p-chlorobenzoylacetate (produced for example from p-chloroacetophenone, diethyl carbonate and sodium hydride with a yield of 72 %) 29 g of phenylhydrazine, 5 ml of glacial acetic acid and 150 ml of ethanol are heated in a nitrogen atmosphere for 1 hour at boiling point. After cooling in an ice bath 3-p-chlorophenyl-1-phenyl-2-pyrazoline-5-one is obtained with a yield of 84 %; F 160.5°-161.5°.

WORKUP

后处理

  1. temperatureare heated in a nitrogen atmosphere for 1 hour
  2. customis obtained with a yield of 84 %
  3. customF 160.5°-161.5°