5-Chloro-2-nitrobenzoic acid → 5-Chloro-2-nitrobenzoyl chloride

반응식

[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([N+:11]([O-:13])=[O:12])=[C:6]([CH:10]=1)[C:7](O)=[O:8].S(Cl)([Cl:16])=O>>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([N+:11]([O-:13])=[O:12])=[C:6]([CH:10]=1)[C:7]([Cl:16])=[O:8]

참가 물질

반응물 2

HCID 172865-Chloro-2-nitrobenzoic acid

HCID 24386Thionyl Chloride

생성물 1

HCID 27236855-Chloro-2-nitrobenzoyl chloride수율 98%

실험 절차

100.00 g (0.50 mol) of 5-chloro-2-nitrobenzoic acid were mixed with 72.20 g (0.61 mol) of thionyl chloride and the mixture was heated under reflux for 2 h. The excess thionyl chloride was removed in vacuo. 106.50 g (ca. 98%) of crude 5-chloro-2-nitro-benzoyl chloride were obtained as an oil.

후처리

temperaturethe mixture was heated
temperatureunder reflux for 2 h
customThe excess thionyl chloride was removed in vacuo

출처 및 근거

ORD 기록: ord-98241a4d407344f4a0ba01242af87eef
출처 데이터셋: uspto-grants-2013_09
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US08541410B2

반응 노트

불러오는 중…