Hydrogen Peroxide → Chalcone epoxide

HRID 442412

반응식

HRID 442412 반응식
[CH:1](=[CH:8][C:9]([C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1)=[O:10])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[OH:17]O.[OH-].[Na+]>CO>[C:2]1([C:1](=[O:17])[CH:8]2[O:10][CH:9]2[C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

참가 물질

5

반응물 3

HCID 784Hydrogen PeroxideHCID 7189CinnamoylbenzeneHCID 14798Sodium Hydroxide

생성물 1

HCID 92219Chalcone epoxide

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

To a mechanically stirred mixture of 83.2 g benzalacetophenone (0.3m), 1000 ml methanol and 120 ml 15% hydrogen peroxide was added 100 ml 2N sodium hydroxide solution, while maintaining the temperature below 30° by external cooling. After completed addition, the mixture was left standing at room temperature for 20 min. The crystalline precipitate was filtered off, washed with water and recrystallized from methanol. There were obtained 59.6 g 1,3-diphenyl-2,3-epoxy-1-propanone; m.p. 90° C.

후처리

  1. temperaturewhile maintaining the temperature below 30° by external cooling
  2. additionaddition
  3. waitthe mixture was left
  4. filtrationThe crystalline precipitate was filtered off
  5. washwashed with water
  6. customrecrystallized from methanol

출처 및 근거

ORD 기록
ord-8b5d335fc60f4e27ac7e20977def2d90
출처 데이터셋
uspto-grants-1977_08
특허 번호
US04045487

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