Phenethyl Isothiocyanate → 1-(4-Chloro-2-(alpha-hydroxybenzyl)benzyl)-3-phenethylthiourea

HRID 442496

반응식

HRID 442496 반응식
[NH2:1][CH2:2][C:3]1[CH:16]=[CH:15][C:14]([Cl:17])=[CH:13][C:4]=1[CH:5]([OH:12])[C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1.[CH2:18]([N:26]=[C:27]=[S:28])[CH2:19][C:20]1[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=1>CO.C(N(CC)CC)C>[Cl:17][C:14]1[CH:15]=[CH:16][C:3]([CH2:2][NH:1][C:27]([NH:26][CH2:18][CH2:19][C:20]2[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=2)=[S:28])=[C:4]([CH:5]([OH:12])[C:6]2[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=2)[CH:13]=1

참가 물질

5

반응물 2

HCID 16741Phenethyl IsothiocyanateHCID 12241006Benzenemethanol,2-(aminomethyl)-5-chloro-a-phenyl-

생성물 1

HCID 214154601-(4-Chloro-2-(alpha-hydroxybenzyl)benzyl)-3-phenethylthiourea

시약·촉매·용매 2

HCID 887Methanol용매2회HCID 8471Triethylamine용매

실험 절차

2-aminomethyl-5-chlorobenzhydrol (10 g; 0.04 mole) in 100 ml methanol and 2 ml triethylamine was treated dropwise with a solution of phenethyl isothiocyanate (8.6 g; 0.053 mole) in 25 ml of methanol. After 16 hours at room temperature the reaction mixture was evaporated and the residue was extracted with petroleum ether. The residual oil was recrystallized from diisopropyl ether to yield 1-(4-chloro-2-(α-hydroxybenzyl)benzyl)-3-phenethylthiourea as a white powder (M.Pt. 97° -- 101° ).

후처리

  1. customAfter 16 hours at room temperature the reaction mixture was evaporated
  2. extractionthe residue was extracted with petroleum ether
  3. customThe residual oil was recrystallized from diisopropyl ether

출처 및 근거

ORD 기록
ord-93903d4497c1482bb535b4bb2fd9bcc5
출처 데이터셋
uspto-grants-1977_08
특허 번호
US04045572

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