Pyridine → Tert-butyl 1-chloroethyl carbonate

HRID 4425

반응식

HRID 4425 반응식
[C:1]([OH:5])([CH3:4])([CH3:3])[CH3:2].Cl[C:7]([O:9][CH:10]([Cl:12])[CH3:11])=[O:8].N1C=CC=CC=1>ClCCl>[C:7](=[O:8])([O:5][C:1]([CH3:4])([CH3:3])[CH3:2])[O:9][CH:10]([Cl:12])[CH3:11]

참가 물질

5

반응물 3

HCID 1049PyridineHCID 6386tert-ButanolHCID 5213051-Chloroethyl chloroformate

생성물 1

HCID 13557091Tert-butyl 1-chloroethyl carbonate

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

In a reactor cooled to +5° C., there are introduced 600 ml of dicloromethane, 43.7 g (0.59 mole) of tert-butanol and 94.7 g (0.66 mole) of α-chloroethyl chloroformate. 57 g (0.72 mole) of pyridine are then added dropwise and with stirring while the temperature is maintained at between 10° and 20° C. The mixture is stirred for 4 hours at room temperature.

후처리

  1. temperatureIn a reactor cooled to +5° C.
  2. temperatureis maintained at between 10° and 20° C
  3. stirringThe mixture is stirred for 4 hours at room temperature

출처 및 근거

ORD 기록
ord-eb26a125028f488199001eac7c1803da
출처 데이터셋
uspto-grants-1988_02
특허 번호
US04725680

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