Sodium borohydride → 1-[4-Hydroxy-4-(4-chlorophenyl)butyl]imidazole

HRID 442510노트

반응식

HRID 442510 반응식
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8](=[O:17])[CH2:9][CH2:10][CH2:11][N:12]2[CH:16]=[CH:15][N:14]=[CH:13]2)=[CH:4][CH:3]=1.[BH4-].[Na+]>CO>[OH:17][CH:8]([C:5]1[CH:4]=[CH:3][C:2]([Cl:1])=[CH:7][CH:6]=1)[CH2:9][CH2:10][CH2:11][N:12]1[CH:16]=[CH:15][N:14]=[CH:13]1

참가 물질

4

반응물 2

HCID 4311764Sodium borohydrideHCID 190783351-[4-(4-Chlorophenyl)butan-4-onyl]imidazole

생성물 1

HCID 203652141-[4-Hydroxy-4-(4-chlorophenyl)butyl]imidazole

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

To a 0° C. solution of 5 g. of the above ketone in 150 ml. of anhydrous methanol was added excess sodium borohydride, and the mixture stirred for 1 hour. After removal of the solvent, a small quantity of water was added and the mixture was extracted with ethyl acetate. The combined extracts were dried over magnesium sulfate and evaporated to afford 1-[4-hydroxy-4-(4-chlorophenyl)butyl]imidazole.

후처리

  1. customTo a 0° C.
  2. customAfter removal of the solvent
  3. additiona small quantity of water was added
  4. extractionthe mixture was extracted with ethyl acetate
  5. dry with materialThe combined extracts were dried over magnesium sulfate
  6. customevaporated

출처 및 근거

ORD 기록
ord-a9be0da4478146a18dbc13aa49ae9732
출처 데이터셋
uspto-grants-1977_08
특허 번호
US04045568

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