Hydrochloric Acid → 2-[(9,10-Methanoanthracen-9(10H)-yl)methyl]-4-methylmorpholine

HRID 442520노트

반응식

HRID 442520 반응식
[NH:1]1[CH2:6][CH2:5][O:4][CH:3]([CH2:7][C:8]23[CH2:22][CH:15]([C:16]4[CH:17]=[CH:18][CH:19]=[CH:20][C:21]=42)[C:14]2[C:9]3=[CH:10][CH:11]=[CH:12][CH:13]=2)[CH2:2]1.[CH2:23]=O.Cl>C(O)=O>[CH3:23][N:1]1[CH2:6][CH2:5][O:4][CH:3]([CH2:7][C:8]23[CH2:22][CH:15]([C:16]4[CH:17]=[CH:18][CH:19]=[CH:20][C:21]=42)[C:14]2[C:9]3=[CH:10][CH:11]=[CH:12][CH:13]=2)[CH2:2]1

참가 물질

5

반응물 3

HCID 313Hydrochloric AcidHCID 712FormaldehydeHCID 214150272-[(9,10-Methanoanthracen-9(10H)-yl)methyl]morpholine

생성물 1

HCID 214150012-[(9,10-Methanoanthracen-9(10H)-yl)methyl]-4-methylmorpholine

시약·촉매·용매 1

HCID 284Formic Acid용매

반응 조건

온도
80 °C

실험 절차

A mixture of 9-(2-morpholinylmethyl)-9,10-dihydro-9,10-methanoanthracene (200 mg), formic acid (600 mg) and 37% formalin (0.25 ml) was stirred at 80° C for 2 hours. 4N Hydrochloric acid was added to the cooled reaction mixture, and the reaction mixture was evaporated to dryness. The residue was diluted with water, basified with aqueous ammonia and extracted with ethyl acetate. The ethyl acetate layer was washed with water, dried over anhydrous sodium sulfate and evaporated to dryness to give 9-(4-methyl-2-morpholinylmethyl)-9,10-dihydro-9,10-methanoanthracene, M.P. 136° - 137° C.

후처리

  1. customthe reaction mixture was evaporated to dryness
  2. additionThe residue was diluted with water
  3. extractionextracted with ethyl acetate
  4. washThe ethyl acetate layer was washed with water
  5. dry with materialdried over anhydrous sodium sulfate
  6. customevaporated to dryness

출처 및 근거

ORD 기록
ord-ff20da63c50b49caac87494fae9fd86e
출처 데이터셋
uspto-grants-1977_08
특허 번호
US04045560

반응 노트

불러오는 중…