Acetic Acid → (2-Acetamido-3-benzoylphenyl)acetic acid

HRID 442534노트

반응식

HRID 442534 반응식
[CH3:1][C:2]1[NH:3][C:4]2[C:9]([C:10]=1[C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1)=[CH:8][CH:7]=[CH:6][C:5]=2[CH2:17][C:18]([OH:20])=[O:19].C(O)(=[O:23])C.O=[O+][O-].[OH2:28]>>[C:2]([NH:3][C:4]1[C:9]([C:10](=[O:23])[C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)=[CH:8][CH:7]=[CH:6][C:5]=1[CH2:17][C:18]([OH:20])=[O:19])(=[O:28])[CH3:1]

참가 물질

5

반응물 4

HCID 176Acetic AcidHCID 962WaterHCID 24823OzoneHCID 20378312(2-Methyl-3-phenyl-1H-indol-7-yl)acetic acid

생성물 1

HCID 15634767(2-Acetamido-3-benzoylphenyl)acetic acid

실험 절차

A solution of 2 g. of α-(2-methyl-3-phenylindol-7-yl)acetic acid in 60 ml. of acetic acid was treated with ozone for 15 minutes. The reaction mixture was treated with 10 ml. of water and allowed to evaporate overnight. The residue (1.7 g.) was recrystallized from isopropanol; yield 1.6 g. (71%); m.p. 188°-190° C.

후처리

  1. additionThe reaction mixture was treated with 10 ml
  2. customto evaporate overnight
  3. customThe residue (1.7 g.) was recrystallized from isopropanol

출처 및 근거

ORD 기록
ord-68c1c2b26d27441d986fd545c910b61b
출처 데이터셋
uspto-grants-1977_08
특허 번호
US04045576

반응 노트

불러오는 중…