Sodium Hydroxide → HCID 12901229, 화합물

HRID 442554노트

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HRID 442554 반응식
[F:1][C:2]1[CH:19]=[CH:18][C:5]([C:6]([C:8]2[CH:9]=[CH:10][CH:11]=[C:12]3[C:16]=2[NH:15][C:14](=[O:17])[CH2:13]3)=[O:7])=[CH:4][CH:3]=1.[OH-:20].[Na+]>O>[NH2:15][C:16]1[C:8]([C:6](=[O:7])[C:5]2[CH:18]=[CH:19][C:2]([F:1])=[CH:3][CH:4]=2)=[CH:9][CH:10]=[CH:11][C:12]=1[CH2:13][C:14]([OH:20])=[O:17]

참가 물질

4

반응물 2

HCID 14798Sodium HydroxideHCID 12901224HCID 12901224, 화합물

생성물 1

HCID 12901229HCID 12901229, 화합물

시약·촉매·용매 1

HCID 962Water용매

실험 절차

A mixture of 1.5 g. (0.006 mole) of 7-(4-fluorobenzoyl) indolin-2-one in 50 ml. of 3N sodium hydroxide was refluxed under nitrogen for 45 min. The solution was cooled, diluted with an equal volume of water, filtered, and the filtrate was extracted two times with 50 ml. of ether. The aqueous basic solution was treated dropwise with glacial acetic acid until a heavy yellow precipitate formed. The precipitate was filtered off, washed thoroughly with water and air-dried. The yield was 1.1 g. (68%); m.p. 136°-137° C.

후처리

  1. additionA mixture of 1.5 g
  2. temperatureThe solution was cooled
  3. filtrationfiltered
  4. extractionthe filtrate was extracted two times with 50 ml
  5. additionThe aqueous basic solution was treated dropwise with glacial acetic acid until a heavy yellow precipitate
  6. customformed
  7. filtrationThe precipitate was filtered off
  8. washwashed thoroughly with water
  9. customair-dried

출처 및 근거

ORD 기록
ord-27c7599dd5554f2db5373b22b8664a2a
출처 데이터셋
uspto-grants-1977_08
특허 번호
US04045576

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