Ammonia → ethyl 4-(2-aminoethyl)-1H-pyrrole-2-carboxylate

HRID 44261노트

반응식

HRID 44261 반응식
[C:1]([CH2:3][C:4]1[CH:5]=[C:6]([C:9]([O:11][CH2:12][CH3:13])=[O:10])[NH:7][CH:8]=1)#[N:2].N>CO.O=[Pt]=O>[NH2:2][CH2:1][CH2:3][C:4]1[CH:5]=[C:6]([C:9]([O:11][CH2:12][CH3:13])=[O:10])[NH:7][CH:8]=1

참가 물질

5

반응물 2

HCID 222AmmoniaHCID 66636709Ethyl 4-(cyanomethyl)-1H-pyrrole-2-carboxylate

생성물 1

HCID 66636613ethyl 4-(2-aminoethyl)-1H-pyrrole-2-carboxylate

시약·촉매·용매 2

HCID 887Methanol용매2회HCID 345198Adams' catalyst용매

실험 절차

To a solution of the product obtained in Step F (7.45 g) in MeOH (1.5 L) there are added 223 ml of a 1.4N solution of NH3 in MeOH and PtO2 (5.2 g). The reaction mixture is placed under an atmosphere of hydrogen and is then stirred for 20 hours at ambient temperature. After filtration and evaporation to dryness, the residue obtained is purified on silica gel (SiO2: gradient CH2Cl2/MeOH with the addition of 1.4N NH3 in the MeOH) to yield the title product which is used directly in the next Step.

후처리

  1. filtrationAfter filtration and evaporation to dryness
  2. customthe residue obtained
  3. customis purified on silica gel (SiO2
  4. additiongradient CH2Cl2/MeOH with the addition of 1.4N NH3 in the MeOH)

출처 및 근거

ORD 기록
ord-b0ea47992e4c4bc1bb3aaa1d2ed9c8b1
출처 데이터셋
uspto-grants-2013_09
특허 번호
US08541412B2

반응 노트

불러오는 중…