Piperazine → HCID 54471836, 화합물

HRID 442704

반응식

HRID 442704 반응식
[O:1]1[CH:3]([CH2:4][O:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH3:23])[CH2:2]1.[NH:24]1[CH2:29][CH2:28][NH:27][CH2:26][CH2:25]1.C(=O)([O-])[O-].[K+].[K+].C(Cl)(Cl)Cl>CN(C)C=O>[OH:1][CH:3]([CH2:4][O:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH3:23])[CH2:2][N:24]1[CH2:29][CH2:28][NH:27][CH2:26][CH2:25]1

참가 물질

6

반응물 4

HCID 4837PiperazineHCID 6212ChloroformHCID 11430Potassium CarbonateHCID 61831Oxirane, 2-[(octadecyloxy)methyl]-

생성물 1

HCID 54471836HCID 54471836, 화합물

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

1,2-Epoxy-3-octadecyloxypropane (5.0 g, 15.3 mmol) is added to a mixture of piperazine (1.94 g, 22.5 mmol) and anhydrous potassium carbonate (100 mg) in dimethyl formamide (60 mL) over a 30 minute period under a nitrogen atmosphere. The resultant mixture is stirred at 80°-90° C. (oil bath temperature) for 48 hours. The reaction mixture is cooled to room temperature and concentrated in vacuo to leave a residue. The residue is stirred with chloroform (125 mL). The undissolved material is filtered in vacuo, and the filtrate is concentrated in vacuo, purified by chromatography and dried in vacuo to afford 1-[2'-hydroxy-3'-octadecyloxypropyl]-piperazine.

후처리

  1. concentrationconcentrated in vacuo
  2. customto leave a residue
  3. filtrationThe undissolved material is filtered in vacuo
  4. concentrationthe filtrate is concentrated in vacuo
  5. custompurified by chromatography
  6. customdried in vacuo

출처 및 근거

ORD 기록
ord-5c6efe180eae410283b11c8a74baa6f1
출처 데이터셋
uspto-grants-1999_04
특허 번호
US05891881

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