Sodium Hydroxide → 6-(methylsulfanyl)-1H-indole-2-carboxylic acid

HRID 442751노트

반응식

HRID 442751 반응식
C[O:2][C:3]([C:5]1[NH:6][C:7]2[C:12]([CH:13]=1)=[CH:11][CH:10]=[C:9]([S:14][CH3:15])[CH:8]=2)=[O:4].[OH-].[Na+]>>[CH3:15][S:14][C:9]1[CH:8]=[C:7]2[C:12]([CH:13]=[C:5]([C:3]([OH:4])=[O:2])[NH:6]2)=[CH:11][CH:10]=1

참가 물질

3

반응물 2

HCID 14798Sodium HydroxideHCID 4715405202584-20-1

생성물 1

HCID 39071736-(methylsulfanyl)-1H-indole-2-carboxylic acid수율 91%

실험 절차

A mixture of methyl-6-methylsulfanyl-1H-indole-2-carboxylate (11.2 g, 51 mmol) and 2N NaOH (125 ml) was heated to reflux temperature for 30 minutes. The clear solution was cooled, and extracted with EtOAc. The aqueous fraction was acidified with concentrated HCl to pH=1, and the precipitate which formed, was filtered and dried to give 6-Methylsulfanyl-1H-indole-2-carboxylic acid (9.6 g, 91.0%).

후처리

  1. temperaturewas heated
  2. temperatureto reflux temperature for 30 minutes
  3. temperatureThe clear solution was cooled
  4. extractionextracted with EtOAc
  5. customthe precipitate which formed
  6. filtrationwas filtered
  7. customdried

출처 및 근거

ORD 기록
ord-145ccd111c3944c6a51053116d174ca3
출처 데이터셋
uspto-grants-1999_04
특허 번호
US05891901

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