Hydrazinecarboxylic acid, ethyl ester → Ethyl N'-[1-(4-chloro-phenyl)-2-hydroxy-ethylidene]-hydrazinecarboxylate

HRID 44287

반응식

HRID 44287 반응식
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8](=O)[CH2:9][OH:10])=[CH:4][CH:3]=1.[NH:12]([C:14]([O:16][CH2:17][CH3:18])=[O:15])[NH2:13]>C(O)C>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8](=[N:13][NH:12][C:14]([O:16][CH2:17][CH3:18])=[O:15])[CH2:9][OH:10])=[CH:4][CH:3]=1

참가 물질

4

반응물 2

HCID 20064Hydrazinecarboxylic acid, ethyl esterHCID 5870851-(4-Chlorophenyl)-2-hydroxyethan-1-one

생성물 1

HCID 86662431Ethyl N'-[1-(4-chloro-phenyl)-2-hydroxy-ethylidene]-hydrazinecarboxylate

시약·촉매·용매 1

HCID 702Ethanol용매

반응 조건

온도
0 °C

실험 절차

A mixture of the compound obtained in Step A (195 mmoles) and ethyl hydrazine-carboxylate (224 mmoles) in ethanol is stirred at reflux for 18 hours. The reaction mixture is cooled to 0° C. and the precipitate formed is filtered off, washed with ethyl ether and dried in vacuo to yield the title product, which is used directly in the next Step.

후처리

  1. temperatureat reflux for 18 hours
  2. customthe precipitate formed
  3. filtrationis filtered off
  4. washwashed with ethyl ether
  5. customdried in vacuo

출처 및 근거

ORD 기록
ord-912b3ef24dad40888753f41f5d19cd2f
출처 데이터셋
uspto-grants-2013_09
특허 번호
US08541412B2

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