Ethanolamine → 2-[2-(4-Nitro-phenyl)-ethylamino]-ethanol

HRID 44293

반응식

HRID 44293 반응식
Br[CH2:2][CH2:3][C:4]1[CH:9]=[CH:8][C:7]([N+:10]([O-:12])=[O:11])=[CH:6][CH:5]=1.[NH2:13][CH2:14][CH2:15][OH:16]>>[N+:10]([C:7]1[CH:8]=[CH:9][C:4]([CH2:3][CH2:2][NH:13][CH2:14][CH2:15][OH:16])=[CH:5][CH:6]=1)([O-:12])=[O:11]

참가 물질

3

반응물 2

HCID 700EthanolamineHCID 792664-Nitrophenethyl bromide

생성물 1

HCID 227227442-[2-(4-Nitro-phenyl)-ethylamino]-ethanol

반응 조건

온도
150 °C

실험 절차

A mixture of 1-(2-bromo-ethyl)-4-nitro-benzene (86.9 mmoles) and 2-amino-ethanol (869 mmoles) is heated at 150° C. under microwave activation for 10 minutes. The reaction mixture is evaporated to dryness and the residue obtained is purified on silica gel (SiO2; gradient DCM/MeOH) to yield the title product, which is used directly in the next Step.

후처리

  1. customThe reaction mixture is evaporated to dryness
  2. customthe residue obtained
  3. customis purified on silica gel (SiO2; gradient DCM/MeOH)

출처 및 근거

ORD 기록
ord-2b4fbf189855456f819977f42058ce7e
출처 데이터셋
uspto-grants-2013_09
특허 번호
US08541412B2

연결된 노트

불러오는 중…