Acetyl chloride → 5-(2-Chloroacetyl)-6-fluoroindolin-2-one

HRID 44299노트

반응식

HRID 44299 반응식
[Cl-:1].[Al+3].[Cl-].[Cl-].[F:5][C:6]1[CH:14]=[C:13]2[C:9]([CH2:10][C:11](=[O:15])[NH:12]2)=[CH:8][CH:7]=1.[C:16](Cl)(=[O:18])[CH3:17]>C(Cl)Cl>[Cl:1][CH2:17][C:16]([C:7]1[CH:8]=[C:9]2[C:13](=[CH:14][C:6]=1[F:5])[NH:12][C:11](=[O:15])[CH2:10]2)=[O:18]

참가 물질

5

반응물 3

HCID 6367Acetyl chlorideHCID 37310136-fluoro-2,3-dihydro-1H-indol-2-oneHCID 6451240Aluminum(III) Chloride

생성물 1

HCID 106093595-(2-Chloroacetyl)-6-fluoroindolin-2-one

시약·촉매·용매 1

HCID 6344Dichloromethane용매

반응 조건

온도
50 °C

실험 절차

20 mL of DCM are added dropwise under nitrogen to aluminium chloride (31.1 mmol) at 0-5° C. 6-Fluoroindolin-2-one (5.18 mmol) and acetyl chloride (6.73 mmol) are added to the mixture. The reaction mixture is heated at 50° C. overnight. The reaction mixture is cooled to ambient temperature and then poured into an ice bath, and the suspension obtained is filtered and then washed with cold water to yield the title product.

후처리

  1. temperatureThe reaction mixture is cooled to ambient temperature
  2. additionpoured into an ice bath
  3. customthe suspension obtained
  4. filtrationis filtered
  5. washwashed with cold water

출처 및 근거

ORD 기록
ord-6d6ce9bf124942cda9586ffa2fb7a844
출처 데이터셋
uspto-grants-2013_09
특허 번호
US08541412B2

반응 노트

불러오는 중…