Sodium Hydroxide → 3-Methyl-2-sulfosuccinic acid sodium salt

HRID 443057

반응식

HRID 443057 반응식
[CH3:1][CH:2]1[CH2:7][C:6](=[O:8])[O:5][C:3]1=[O:4].[S:9](=[O:12])(=[O:11])=[O:10].[OH-:13].[Na+:14]>ClCCCl.O>[Na+:14].[CH3:1][CH:2]([C:3]([O-:13])=[O:4])[CH:7]([S:9]([OH:12])(=[O:11])=[O:10])[C:6]([O-:5])=[O:8].[Na+:14]

참가 물질

6

반응물 3

HCID 14798Sodium HydroxideHCID 20051Methylsuccinic anhydrideHCID 24682Sulfur trioxide2회

생성물 1

HCID 1317212183-Methyl-2-sulfosuccinic acid sodium salt

시약·촉매·용매 2

HCID 111,2-Dichloroethane용매2회HCID 962Water용매2회

실험 절차

3-Methyl-2-sulfosuccinic acid sodium salt was prepared as follows. 20 g Methylsuccinic anhydride was dissolved in 40 g 1,2-dichloroethane. 15.4 g solid sulfur trioxide was melted and added in portions to 140 g 1,2-dichloroethane in an addition funnel. The sulfur trioxide solution was added slowly to the anhydride solution and stirred overnight. 50 mL water was then added, followed by 7 g sodium hydroxide dissolved in 50 mL water. The layers were separated and the 1,2-dichloroethane layer was again extracted with 50 mL water. The combined water layers were stripped to give 42.2 g yellowish solid. 1H-NMR (D2O) 2.65-2.80 ppm m, 2.47-2.58 ppm m, 1.04 ppm d J=7.07 Hz.

후처리

  1. customThe layers were separated
  2. extractionthe 1,2-dichloroethane layer was again extracted with 50 mL water

출처 및 근거

ORD 기록
ord-396b130494514bb19587cc5a9cedbf68
출처 데이터셋
uspto-grants-1999_04
특허 번호
US05892057

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