Hydrochloric Acid → 4-(3-Methylphenyl)-4-hydroxypiperidine hydrochloride

HRID 443216노트

반응식

HRID 443216 반응식
C(OC([N:8]1[CH2:13][CH2:12][C:11]([C:15]2[CH:20]=[CH:19][CH:18]=[C:17]([CH3:21])[CH:16]=2)([OH:14])[CH2:10][CH2:9]1)=O)(C)(C)C.[ClH:22]>CCOC(C)=O>[ClH:22].[CH3:21][C:17]1[CH:16]=[C:15]([C:11]2([OH:14])[CH2:10][CH2:9][NH:8][CH2:13][CH2:12]2)[CH:20]=[CH:19][CH:18]=1

참가 물질

4

반응물 2

HCID 313Hydrochloric AcidHCID 21193300N-t-Butoxycarbonyl-4-(3-methylphenyl)-4-hydroxy piperidine

생성물 1

HCID 211931674-(3-Methylphenyl)-4-hydroxypiperidine hydrochloride

시약·촉매·용매 1

HCID 8857Ethyl Acetate용매

실험 절차

To a solution of N-t-butoxycarbonyl-4-(3-methylphenyl)-4-hydroxy piperidine (0.546 mg, 1.87 mmol) in EtOAc (30 ml) at 0° C. was bubbled gasseous HCl until saturated. After 10 min the solvent was evaporated in vacuo to afford the title compound of sufficient purity to be used in the next step.

후처리

  1. customAfter 10 min the solvent was evaporated in vacuo

출처 및 근거

ORD 기록
ord-8446683b209e4700a6482f9df30aa441
출처 데이터셋
uspto-grants-1999_04
특허 번호
US05891889

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