Ethyl 1-phenylpiperidine-4-carboxylate → 1-Phenylpiperidine-4-carboxylic acid

HRID 443248노트

반응식

HRID 443248 반응식
[C:1]([CH:6]1[CH2:11][CH2:10][N:9]([C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)[CH2:8][CH2:7]1)([O:3]CC)=[O:2].[OH-].[Na+]>CO>[C:1]([CH:6]1[CH2:7][CH2:8][N:9]([C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)[CH2:10][CH2:11]1)([OH:3])=[O:2]

참가 물질

4

반응물 2

HCID 6470Ethyl 1-phenylpiperidine-4-carboxylateHCID 14798Sodium Hydroxide

생성물 1

HCID 30239901-Phenylpiperidine-4-carboxylic acid

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

The product from Step C was dissolved in methanol and 5% aqueous sodium hydroxide added. After 1 h, methanol was removed in vacuo, and the residue partitioned between ethyl acetate and 10% aqueous HCl. The organic layer was washed with saturated brine, and dried over MgSO4. Filtration and concentration provided the title compound.

후처리

  1. custommethanol was removed in vacuo
  2. customthe residue partitioned between ethyl acetate and 10% aqueous HCl
  3. washThe organic layer was washed with saturated brine
  4. dry with materialdried over MgSO4
  5. filtrationFiltration and concentration

출처 및 근거

ORD 기록
ord-ec91670ab7f94eee85c88d662d4d0255
출처 데이터셋
uspto-grants-1999_04
특허 번호
US05891889

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