Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Diisopropylamine → 2-(2-Hydroxy-2-p-methoxyphenylethyl)-6-methylpyrazine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Diisopropylamine | HCID 7912 | — |
| 반응물 | 2,6-Dimethylpyrazine | HCID 7938 | — |
| 반응물 | 4-Methoxybenzaldehyde | HCID 31244 | — |
| 반응물 | Butyllithium | HCID 178418339 | — |
| 용매 | Water | HCID 962 | — |
| 용매 | Diethyl Ether | HCID 3283 | — |
| 용매 | Hexane | HCID 8058 | — |
| 생성물 | 2-(2-Hydroxy-2-p-methoxyphenylethyl)-6-methylpyrazine | HCID 572755 | — |
반응 단계
A solution of 5.05 grams (50 mmole) of diisopropylamine in 40 milliliters of ether was added to 47.1 mole butyllithium in hexane at 0° C. After stirring the resulting solution for 15 minutes, 5.4 grams (50 mmole) of 2,6-dimethylpyrazine in 50 milliliters of ether were added slowly and the reaction mixture was stirred at 0° C. for 30 minutes. A solution of 5.4 grams (40 mmole) of p-methoxybenzaldehyde in 40 milliliters of ether was added, and stirring at 0° C. was continued for an additional 30 minutes. Water was added, the organic phase was separated, washed with water and dried over magnesium sulfate.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04259969 |
| 출처 데이터셋 | uspto-grants-1981_04 |
| ORD ID | ord-b78624bf854a48b6ac2689b539b97161 |
| 출처 메모 | uspto-grants-1981_04 |