反应详情

A solution of 5.05 grams (50 mmole) of diisopropylamine in 40 milliliters of ether was added to 47.1 mole butyllithium in hexane at 0° C. After stirring the resulting solution for 15 minutes, 5.4 grams (50 mmole) of 2,6-dimethylpyrazine in 50 milliliters of ether were added slowly and the reaction mixture was stirred at 0° C. for 30 minutes. A solution of 5.4 grams (40 mmole) of p-methoxybenzaldehyde in 40 milliliters of ether was added, and stirring at 0° C. was continued for an additional 30 minutes. Water was added, the organic phase was separated, washed with water and dried over magnesium sulfate.

1. stirringthe reaction mixture was stirred at 0° C. for 30 minutes
2. stirringstirring at 0° C.
3. waitwas continued for an additional 30 minutes
4. customthe organic phase was separated
5. washwashed with water
6. dry with materialdried over magnesium sulfate