Hydrochloric Acid → 6-(Hydroxymethyl)pyridin-3-ol hydrochloride

HRID 443433노트

반응식

HRID 443433 반응식
C([O:4][CH2:5][C:6]1[CH:11]=[CH:10][C:9]([O:12]C(=O)C)=[CH:8][N:7]=1)(=O)C.[ClH:16]>CC(CC)=O>[ClH:16].[OH:12][C:9]1[CH:10]=[CH:11][C:6]([CH2:5][OH:4])=[N:7][CH:8]=1

참가 물질

4

반응물 2

HCID 313Hydrochloric AcidHCID 2715886-(Acetoxymethyl)pyridin-3-yl acetate

생성물 1

HCID 187584236-(Hydroxymethyl)pyridin-3-ol hydrochloride

시약·촉매·용매 1

HCID 6569Methyl Ethyl Ketone용매

실험 절차

220.0 g of the above ester is added to 2,200 ml of 6N-hydrochloric acid and the resulting solution is refluxed for 18 hours. Then, the solution is evaporated to leave an oily viscous residue. This residue is digested with ethyl methyl ketone to yield 5-hydroxy-2-pyridinemethanol hydrochloride melting at 122°-123°. (The corresponding free base is prepared by adding a saturated solution of potassium carbonate to the hydrochloride, extracting the resulting suspension with chloroform, drying the chloroform extract over sodium sulfate, filtering and evaporating the filtrate to yield the free base.)

후처리

  1. temperaturethe resulting solution is refluxed for 18 hours
  2. customThen, the solution is evaporated
  3. customto leave an oily viscous residue

출처 및 근거

ORD 기록
ord-a97f9913d0b648d49bdeee3150ffad05
출처 데이터셋
uspto-grants-1981_04
특허 번호
US04260620

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