Acetohydrazide → HCID 23467590, 화합물

HRID 443516노트

반응식

HRID 443516 반응식
[O:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[C:6]1[CH2:7][CH2:8][C:9](=O)[NH:10][N:11]=1.Cl[C:14]1[N:15]=[N:16]C(C2OC=CC=2)=C[CH:19]=1.C(NN)(=O)C>C(O)CCC>[CH3:19][C:14]1[N:10]2[N:11]=[C:6]([C:2]3[O:1][CH:5]=[CH:4][CH:3]=3)[CH:7]=[CH:8][C:9]2=[N:16][N:15]=1

참가 물질

5

반응물 3

HCID 14039AcetohydrazideHCID 234675803-Chloro-6-(2-furanyl)pyridazineHCID 54470727HCID 54470727, 화합물

생성물 1

HCID 23467590HCID 23467590, 화합물

시약·촉매·용매 1

HCID 2631-Butanol용매

실험 절차

As for Example 5, 4,5-dihydro-6-(2-furyl)-3(2H)-pyridazinone is converted to 3-chloro-6-(2-furyl)pyridazine. A 1.5 g. sample of the preceding compound, 1.2 g. of acethydrazide in 50 ml. of n-butyl alcohol is refluxed for 48 hours. The solvent is removed under reduced pressure and the residue is partitioned between dichloromethane and dilute sodium hydroxide. The dichloromethane layer is washed with water, dried over magnesium sulfate, filtered and concentrated. The residue is purified by conventional means to give the product of the Example.

후처리

  1. customThe solvent is removed under reduced pressure
  2. customthe residue is partitioned between dichloromethane and dilute sodium hydroxide
  3. washThe dichloromethane layer is washed with water
  4. dry with materialdried over magnesium sulfate
  5. filtrationfiltered
  6. concentrationconcentrated
  7. customThe residue is purified by conventional means
  8. customto give the product of the Example

출처 및 근거

ORD 기록
ord-9a4accac960040f7bcdc01000eb6a2ad
출처 데이터셋
uspto-grants-1981_04
특허 번호
US04260756

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