Sodium borohydride → 5-Chloro-2'-fluoro-2-iodobenzhydrol

HRID 443578노트

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HRID 443578 반응식
[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([I:17])=[C:6]([CH:16]=1)[C:7]([C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=1[F:15])=[O:8].[BH4-].[Na+]>C(O)C.O>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([I:17])=[C:6]([CH:16]=1)[CH:7]([OH:8])[C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=1[F:15]

참가 물질

5

반응물 2

HCID 4311764Sodium borohydrideHCID 12948263(5-Chloro-2-iodophenyl)(2-fluorophenyl)methanone

생성물 1

HCID 205631225-Chloro-2'-fluoro-2-iodobenzhydrol

시약·촉매·용매 2

HCID 702Ethanol용매HCID 962Water용매

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온도
0 °C

실험 절차

A mixture of 54 g (0.15 mole) of 5-chloro-2'-fluoro-2-iodobenzophenone and 28.4 g (0.75 mole) of sodium borohydride in 1000 ml of ethanol was stirred at 0° C. for 15 min. The solution was diluted with water and extracted with ether. The ether solution was washed with water, dried over anhydrous sodium sulfate, and concentrated at reduced pressure to give a deep yellow oil.

후처리

  1. extractionextracted with ether
  2. washThe ether solution was washed with water
  3. dry with materialdried over anhydrous sodium sulfate
  4. concentrationconcentrated at reduced pressure
  5. customto give a deep yellow oil

출처 및 근거

ORD 기록
ord-8f621fad600a4216a978b8e01061c24f
출처 데이터셋
uspto-grants-1981_04
특허 번호
US04260772

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