Diethylamine → 1-[4-Chloro-2-benzoylphenyl]-3-phthalimidopropyne

HRID 443595노트

반응식

HRID 443595 반응식
C1(P(C2C=CC=CC=2)C2C=CC=CC=2)C=CC=CC=1.[Cl:20][C:21]1[CH:22]=[CH:23][C:24](I)=[C:25]([CH:34]=1)[C:26]([C:28]1[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=1)=[O:27].C(NCC)C.[CH2:41]([N:44]1[C:48](=[O:49])[C:47]2=[CH:50][CH:51]=[CH:52][CH:53]=[C:46]2[C:45]1=[O:54])[C:42]#[CH:43]>[Pd](Cl)Cl.C(Cl)Cl>[Cl:20][C:21]1[CH:22]=[CH:23][C:24]([C:43]#[C:42][CH2:41][N:44]2[C:48](=[O:49])[C:47]3=[CH:50][CH:51]=[CH:52][CH:53]=[C:46]3[C:45]2=[O:54])=[C:25]([C:26](=[O:27])[C:28]2[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=2)[CH:34]=1

참가 물질

7

반응물 4

HCID 8021DiethylamineHCID 11776TriphenylphosphineHCID 81644N-prop-2-ynylphthalimideHCID 129482625-Chloro-2-iodobenzophenone

생성물 1

HCID 128782521-[4-Chloro-2-benzoylphenyl]-3-phthalimidopropyne

시약·촉매·용매 2

HCID 24290Palladium Chloride촉매HCID 6344Dichloromethane용매

실험 절차

A mixture of 0.71 g (4.0 mmole) of palladium chloride, 2.1 g (8.0 mmole) of triphenylphosphine, 0.80 g (4.2 mmole) of cuprous iodide, 68.8 g (0.20 mole) of 5-chloro-2-iodobenzophenone, 200 ml of diethylamine, and 400 ml of methylene chloride was stirred at room temperature under argon until complete solution was obtained. In one portion, 40.0 g (0.22 mole) of N-propargylphthalimide was added to the solution and the resulting mixture stirred for 20 hr. The volatiles were removed at reduced pressure and the residue was triturated with 200 ml of iospropanol. The resulting percipitate was collected by filtration to give crude end product. Recrystallization from acetone gave cream colored prisms, mp 148°-150° C.

후처리

  1. customwas obtained
  2. stirringthe resulting mixture stirred for 20 hr
  3. customThe volatiles were removed at reduced pressure
  4. customthe residue was triturated with 200 ml of iospropanol
  5. filtrationThe resulting percipitate was collected by filtration
  6. customto give crude end product
  7. customRecrystallization from acetone
  8. customgave cream colored prisms, mp 148°-150° C.

출처 및 근거

ORD 기록
ord-e7cbafc746fb4a48924b9e97abb5a45b
출처 데이터셋
uspto-grants-1981_04
특허 번호
US04260773

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