Hydrochloric Acid → p-{[2-(2-Naphthyloxy)ethyl]amino}benzoic acid

HRID 443641노트

반응식

HRID 443641 반응식
[CH:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]=[CH:3][C:2]=1[O:11][CH2:12][CH2:13][NH:14][C:15]1[CH:25]=[CH:24][C:18]([C:19]([O:21]CC)=[O:20])=[CH:17][CH:16]=1.[OH-].[K+].C(O)C.O.Cl>O>[CH:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]=[CH:3][C:2]=1[O:11][CH2:12][CH2:13][NH:14][C:15]1[CH:25]=[CH:24][C:18]([C:19]([OH:21])=[O:20])=[CH:17][CH:16]=1

참가 물질

6

반응물 4

HCID 313Hydrochloric AcidHCID 14797Potassium HydroxideHCID 19096565Water ethanolHCID 23468273Ethyl p-{[2-(2-naphthyloxy)ethyl]amino}benzoate

생성물 1

HCID 23468295p-{[2-(2-Naphthyloxy)ethyl]amino}benzoic acid

시약·촉매·용매 1

HCID 962Water용매

실험 절차

A mixture of 3.0 g. of ethyl p-{[2-(2-naphthyloxy)ethyl]amino}benzoate, and 3.0 g. of potassium hydroxide in 200 ml. of ethanol-water (95:5) is refluxed for 3 hours. The mixture is diluted with 100 ml. of water and brought to pH 6.0 with concentrated hydrochloric acid. The mixture is filtered and the solid washed with 50 ml. of water and 20 ml. of cold ethanol-water (4:1) to give the product, m.p. 208°-211° C.

후처리

  1. additionA mixture of 3.0 g
  2. additionThe mixture is diluted with 100 ml
  3. filtrationThe mixture is filtered
  4. washthe solid washed with 50 ml
  5. customof cold ethanol-water (4:1) to give the product, m.p. 208°-211° C.

출처 및 근거

ORD 기록
ord-bb52f120c6ca42b69955e132f443f42f
출처 데이터셋
uspto-grants-1981_04
특허 번호
US04260816

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