Ethanol → 5,6,7,8-Tetrahydroquinazoline-2,4(1H,3H)-dione
반응식
O=[C:2]1[CH2:7][CH2:6][CH2:5][CH2:4][CH:3]1[C:8]#[N:9].[NH2:10][C:11](N)=[O:12].CC[OH:16]>Cl>[NH:10]1[C:2]2[CH2:7][CH2:6][CH2:5][CH2:4][C:3]=2[C:8](=[O:16])[NH:9][C:11]1=[O:12]참가 물질
5
반응 조건
- 온도
- 0 °C
실험 절차
A solution of 2-oxocyclohexanecarbonitrile (615 mg, 5.0 mmol) and urea (600 mg, 10.0 mmol) in 1.25 N HCl in EtOH (20 mL) was refluxed over night. After it was cooled down to 0° C., the precipitation was collected by filtration, washed with EtOH/H2O, and dried under vacuum overnight to give the product as a white solid. 1H NMR (400 MHz, CD3OD) δ1.67-1.80 (m, 4H), 2.25-2.29 (m, 2H), 2.38-2.42 (m, 2H). MS 167 (MH+).
후처리
- customthe precipitation
- filtrationwas collected by filtration
- washwashed with EtOH/H2O
- customdried under vacuum overnight
출처 및 근거
- ORD 기록
- ord-83fd9f5accae48eb94cbb22e21e48926
- 출처 데이터셋
- uspto-grants-2013_09
- 특허 번호
- US08541421B2
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