HCID 178488043, 화합물 → HCID 178524063, 화합물

HRID 443822노트

반응식

HRID 443822 반응식
C[O:2][C:3]1[CH:12]=[CH:11][C:10]2[NH:9][C:8]3=[CH:13][C:14]([C:16]([OH:18])=[O:17])=[N:15][N:7]3[C:6](=[O:19])[C:5]=2[CH:4]=1>Br.C(O)(=O)C.O>[OH:2][C:3]1[CH:12]=[CH:11][C:10]2[NH:9][C:8]3=[CH:13][C:14]([C:16]([OH:18])=[O:17])=[N:15][N:7]3[C:6](=[O:19])[C:5]=2[CH:4]=1

참가 물질

5

반응물 1

HCID 178488043HCID 178488043, 화합물

생성물 1

HCID 178524063HCID 178524063, 화합물

시약·촉매·용매 3

HCID 176Acetic Acid용매HCID 260Hydrogen Bromide용매HCID 962Water용매

실험 절차

A suspension of 4,9-dihydro-7-methoxy-9-oxo-pyrazolo[5,1-b]quinazoline-2-carboxylic acid (2.0 g; 0.0077 mole) in 48% hydrobromic acid (30 ml) and glacial acetic acid (50 ml) is refluxed for 23 hrs. The mixture is cooled and then diluted with water (25 ml). The product, which precipitates out, is collected by filtration and recrystallized from DMF-Ether (1:1, 90 ml). Yield 1.1 g; mp 285°-286° C. (d).

후처리

  1. temperatureis refluxed for 23 hrs
  2. temperatureThe mixture is cooled
  3. customThe product, which precipitates out
  4. filtrationis collected by filtration
  5. customrecrystallized from DMF-Ether (1:1, 90 ml)

출처 및 근거

ORD 기록
ord-18fa4349312740089f5bb05920fe843a
출처 데이터셋
uspto-grants-1981_04
특허 번호
US04261996

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