5-(Methylsulfanyl)-2-nitrobenzoic acid → 2-Amino-5-(methylsulfanyl)benzoic acid

HRID 443826노트

반응식

HRID 443826 반응식
[CH3:1][S:2][C:3]1[CH:4]=[CH:5][C:6]([N+:12]([O-])=O)=[C:7]([CH:11]=1)[C:8]([OH:10])=[O:9].[H][H]>[Ni].CO>[CH3:1][S:2][C:3]1[CH:4]=[CH:5][C:6]([NH2:12])=[C:7]([CH:11]=1)[C:8]([OH:10])=[O:9]

참가 물질

5

반응물 2

HCID 89345765-(Methylsulfanyl)-2-nitrobenzoic acidHCID 178418361HCID 178418361, 화합물2회

생성물 1

HCID 127132522-Amino-5-(methylsulfanyl)benzoic acid

시약·촉매·용매 2

HCID 935Nickel촉매HCID 887Methanol용매

실험 절차

A mixture of 5-methylthio-2-nitrobenzoic acid (25.4 g; 0.119 mole), methanol (200 ml) and Raney nickel (2 g) is shaken in an atmosphere of hydrogen at 50 lb pressure when theoretical amount of hydrogen is absorbed. The catalyst is filtered off and the filtrate evaporated to dryness. The residue is recrystallized from etheriso-Pr2O. Yield 7.6 g; mp 145°-150°.

후처리

  1. customis absorbed
  2. filtrationThe catalyst is filtered off
  3. customthe filtrate evaporated to dryness
  4. customThe residue is recrystallized from etheriso-Pr2O

출처 및 근거

ORD 기록
ord-b25cfef8cded444f874966915cfbe930
출처 데이터셋
uspto-grants-1981_04
특허 번호
US04261996

반응 노트

불러오는 중…