Hydrochloric Acid → H-(D)Ala-Gly-OBzl.hydrochloride

HRID 443917노트

반응식

HRID 443917 반응식
[NH:1](C(OC(C)(C)C)=O)[C@@H:2]([C:4]([NH:6][CH2:7][C:8]([O:10][CH2:11][C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1)=[O:9])=[O:5])[CH3:3].[ClH:25].CCOCC>O1CCOCC1>[NH2:1][C@@H:2]([C:4]([NH:6][CH2:7][C:8]([O:10][CH2:11][C:12]1[CH:13]=[CH:14][CH:15]=[CH:16][CH:17]=1)=[O:9])=[O:5])[CH3:3].[ClH:25]

참가 물질

5

반응물 3

HCID 313Hydrochloric AcidHCID 3283Diethyl EtherHCID 15567200Boc-(D)Ala-Gly-OBzl

생성물 1

HCID 131712174H-(D)Ala-Gly-OBzl.hydrochloride

시약·촉매·용매 1

HCID 312751,4-Dioxane용매

실험 절차

3.4 g of Boc-(D)Ala-Gly-OBzl are dissolved in 50 ml of dioxane containing HCl and left to stand for one hour. The volume of the solution is reduced under vacuum and an excess of ether added. The precipitated salt is filtered off, dried and used as such for the coupling reaction.

후처리

  1. waitleft
  2. filtrationThe precipitated salt is filtered off
  3. customdried
  4. customsuch for the coupling reaction

출처 및 근거

ORD 기록
ord-bde701a623bf43e4a1e85e704975ba84
출처 데이터셋
uspto-grants-1981_04
특허 번호
US04261888

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