Water → 5-Oxo-1-phenylhexan-3-yl acetate

HRID 443961노트

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HRID 443961 반응식
[OH:1][CH:2]([CH2:7][CH2:8][C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1)[CH2:3][C:4](=[O:6])[CH3:5].[C:15](OC(=O)C)(=[O:17])[CH3:16].N1C=CC=CC=1.O>C(Cl)Cl>[C:15]([O:1][CH:2]([CH2:7][CH2:8][C:9]1[CH:10]=[CH:11][CH:12]=[CH:13][CH:14]=1)[CH2:3][C:4](=[O:6])[CH3:5])(=[O:17])[CH3:16]

참가 물질

6

반응물 4

HCID 962WaterHCID 1049PyridineHCID 7918Acetic AnhydrideHCID 11458200HCID 11458200, 화합물

생성물 1

HCID 234660175-Oxo-1-phenylhexan-3-yl acetate

시약·촉매·용매 1

HCID 6344Dichloromethane용매

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온도
0 °C

실험 절차

To a solution of 850 mg of 4-hydroxy-6-phenylhexan-2-one (T. Mukaiyama et al., Chemistry Letters 1976, 95) in 10 ml of methylene chloride were added 1 ml of acetic anhydride and 0.8 ml of pyridine under ice-cooling at 0° C., and then stirring was continued for further 1 hr at room temperature. The reaction mixture was poured into water, the methylene chloride layer was washed with water, dried over anhydrous sodium sulfate, and the solvent was evaporated to afford 1.10 g of the desired compound.

후처리

  1. washthe methylene chloride layer was washed with water
  2. dry with materialdried over anhydrous sodium sulfate
  3. customthe solvent was evaporated

출처 및 근거

ORD 기록
ord-3af3535ac29b46e584147b8beb213a33
출처 데이터셋
uspto-grants-1981_04
특허 번호
US04262013

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