Hydrochloric Acid → 5-Bromo-2,3-dihydro-3,3-dimethyl-2-hydroxybenzofuran

HRID 444078노트

반응식

HRID 444078 반응식
C[O:2][C:3]1[CH:8]=[CH:7][C:6]([Br:9])=[CH:5][C:4]=1[C:10]([CH3:14])([CH3:13])[CH:11]=[O:12].Cl.N1C=CC=CC=1.Cl>CCOCC>[Br:9][C:6]1[CH:7]=[CH:8][C:3]2[O:2][CH:11]([OH:12])[C:10]([CH3:14])([CH3:13])[C:4]=2[CH:5]=1

참가 물질

5

반응물 3

HCID 313Hydrochloric AcidHCID 10176127Pyridinium chlorideHCID 205362232-(5-Bromo-2-methoxyphenyl)-2-methylpropanal

생성물 1

HCID 205362245-Bromo-2,3-dihydro-3,3-dimethyl-2-hydroxybenzofuran

시약·촉매·용매 1

HCID 3283Diethyl Ether용매

실험 절차

2-(2-Methoxy-5-bromophenyl)-2-methyl-1-propanal (30 g, 0.115 mole) was added to molten pyridine hydrochloride (60 g) and the mixture heated with stirring at 190°-200° C. for 50 minutes. Addition to ice-water containing a little hydrochloric acid and isolated through ether gave, after recrystallisation from petroleum ether (b.p. 80°-100° C.) 11.7 g (42%) title product m.p. 114°-5° C.

후처리

  1. temperaturethe mixture heated
  2. customgave
  3. customafter recrystallisation from petroleum ether (b.p. 80°-100° C.) 11.7 g (42%) title product m.p. 114°-5° C.

출처 및 근거

ORD 기록
ord-e6cc82d3360d47439abb58b9255c5d94
출처 데이터셋
uspto-grants-1981_04
특허 번호
US04263037

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