Diethyl Ether → 2-(2-Methoxy-5-cyanophenyl)-2-methyl-1-propanal

HRID 444089노트

반응식

HRID 444089 반응식
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6](Br)=[CH:5][C:4]=1[C:10]([CH3:14])([CH3:13])[CH:11]=[O:12].[CH3:15][N:16](C)C=O.C(OCC)C>O.Cl>[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([C:15]#[N:16])=[CH:5][C:4]=1[C:10]([CH3:14])([CH3:13])[CH:11]=[O:12]

참가 물질

6

반응물 3

HCID 3283Diethyl EtherHCID 6228DimethylformamideHCID 205362232-(5-Bromo-2-methoxyphenyl)-2-methylpropanal

생성물 1

HCID 205362562-(2-Methoxy-5-cyanophenyl)-2-methyl-1-propanal

시약·촉매·용매 2

HCID 313Hydrochloric Acid용매HCID 962Water용매

실험 절차

2-(2-Methoxy-5-bromophenyl)-2-methyl-1-propanal (9.5 g), prepared as in Example 5(d), cuprous cyanide (4.0 g) and dimethylformamide (20 ml) were heated under reflux with stirring for 3 hours. A solution of ferric chloride (7.3 g) in water (25 ml) and hydrochloric acid (3.5 ml conc) was added to the cooled reaction mixture which was then heated at 60°-70° C. for 5 minutes. Isolation of the product through diethyl ether yielded, after recrystallisation from ethanol, 3 g of pure product, mp 115°-117° C.

후처리

  1. temperaturewere heated
  2. temperatureunder reflux
  3. temperaturewas then heated at 60°-70° C. for 5 minutes
  4. customafter recrystallisation from ethanol, 3 g of pure product, mp 115°-117° C.

출처 및 근거

ORD 기록
ord-b065fcfa0a9444ab950354ce38f19a29
출처 데이터셋
uspto-grants-1981_04
특허 번호
US04263037

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