Sodium Hydroxide → 10,11-Dihydro-11-oxodibenzo[b,f][1,4]thiazepin-3-carboxylic acid
반응식
[O:1]=[C:2]1[C:8]2[CH:9]=[CH:10][C:11]([C:13]([O:15]C)=[O:14])=[CH:12][C:7]=2[S:6][C:5]2[CH:17]=[CH:18][CH:19]=[CH:20][C:4]=2[NH:3]1.[OH-].[Na+]>O1CCCC1>[O:1]=[C:2]1[C:8]2[CH:9]=[CH:10][C:11]([C:13]([OH:15])=[O:14])=[CH:12][C:7]=2[S:6][C:5]2[CH:17]=[CH:18][CH:19]=[CH:20][C:4]=2[NH:3]1참가 물질
4
실험 절차
Dissolve 1.49 gm of the ester of Example 2 in 50 cc of tetrahydrofuran. Add 40 cc of 10% sodium hydroxide and stir at room temperature for 3 hours. Evaporate the tetrahydrofuran and extract the aqueous residue with ethyl acetate. Acidify and separate the precipitate by filtration. Wash the precipitate well with water and dry in vacuo to obtain the title product (m.p. 362°-364° C.).
후처리
- customEvaporate the tetrahydrofuran
- extractionextract the aqueous residue with ethyl acetate
- customseparate the precipitate
- filtrationby filtration
- washWash the precipitate well with water
- customdry in vacuo
출처 및 근거
- ORD 기록
- ord-6a01973b78f14887b3cdac652343957a
- 출처 데이터셋
- uspto-grants-1981_04
- 특허 번호
- US04263207
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