3-Hydroxypropionic acid → beta-Carboxyethyl 10,11-Dihydro-11-oxodibenzo[b,f][1,4]thiazepin-3-carboxylate

HRID 444168

반응식

HRID 444168 반응식
Cl[C:2]([C:4]1[CH:19]=[CH:18][C:7]2[C:8](=[O:17])[NH:9][C:10]3[CH:16]=[CH:15][CH:14]=[CH:13][C:11]=3[S:12][C:6]=2[CH:5]=1)=[O:3].[Na].[OH:21][CH2:22][CH2:23][C:24]([OH:26])=[O:25]>O1CCCC1>[O:17]=[C:8]1[C:7]2[CH:18]=[CH:19][C:4]([C:2]([O:21][CH2:22][CH2:23][C:24]([OH:26])=[O:25])=[O:3])=[CH:5][C:6]=2[S:12][C:11]2[CH:13]=[CH:14][CH:15]=[CH:16][C:10]=2[NH:9]1

참가 물질

5

반응물 3

HCID 681523-Hydroxypropionic acidHCID 5360545SodiumHCID 234644803-Chlorocarbonyl-10,11-dihydro-11-oxodibenzo[b,f][1,4]thiazepin

생성물 1

HCID 23464478beta-Carboxyethyl 10,11-Dihydro-11-oxodibenzo[b,f][1,4]thiazepin-3-carboxylate

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

Dissolve 1.0 gm. of 3-chlorocarbonyl-10,11-dihydro-11-oxodibenzo[b,f][1,4]thiazepine in 20 cc. of tetrahydrofuran and add 1.0 gm. of the sodium salt of β-hydroxypropionic acid. Stir the mixture at room temperature for 18 hours. Filter and evaporate the filtrate to dryness. Recrystallize the solid residue from ethanol to obtain the title product.

후처리

  1. dissolutionDissolve 1.0 gm
  2. filtrationFilter
  3. customevaporate the filtrate to dryness
  4. customRecrystallize the solid residue from ethanol

출처 및 근거

ORD 기록
ord-b6769a818fde43e9850d0873255c633c
출처 데이터셋
uspto-grants-1981_04
특허 번호
US04263207

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