Hydrochloric Acid → 4-Ethoxy-7-methylcoumarin

HRID 444221

반응식

HRID 444221 반응식
Cl.[OH:2][C:3]1[C:12]2[C:7](=[CH:8][C:9]([CH3:13])=[CH:10][CH:11]=2)[O:6][C:5](=[O:14])[CH:4]=1.[CH2:15](O)[CH3:16]>>[CH2:15]([O:2][C:3]1[C:12]2[C:7](=[CH:8][C:9]([CH3:13])=[CH:10][CH:11]=2)[O:6][C:5](=[O:14])[CH:4]=1)[CH3:16]

참가 물질

4

반응물 3

HCID 313Hydrochloric AcidHCID 702EthanolHCID 546853074-Hydroxy-7-methylcoumarin

생성물 1

HCID 6889444-Ethoxy-7-methylcoumarin수율 72%

실험 절차

Dry hydrogen chloride was passed through a solution of 4-hydroxy-7-methylcoumarin (14 g; 0.08 mole) in ethanol (300 ml) for 15 mins and the resulting solution was refluxed for 30 minutes. After cooling, the solvent was removed in vacuo and the residue recrystallized from ethanol to give 11.74 g (72%) of product of m.p. 142°-143° C.; (Found; C, 70.24; H, 5.95; C12H12O3 requires; C, 70.60; H, 5.88%).

후처리

  1. temperaturethe resulting solution was refluxed for 30 minutes
  2. temperatureAfter cooling
  3. customthe solvent was removed in vacuo
  4. customthe residue recrystallized from ethanol

출처 및 근거

ORD 기록
ord-ed20385ddde44873bbe343fb9dc39b19
출처 데이터셋
uspto-grants-1981_04
특허 번호
US04263299

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