Hydrochloric Acid → 9-Chloro-9-(4-diethylaminophenyl)-10-phenylacridan

HRID 444297노트

반응식

HRID 444297 반응식
[CH2:1]([N:3]([CH2:32][CH3:33])[C:4]1[CH:9]=[CH:8][C:7]([C:10]2(OC)[C:23]3[CH:22]=[CH:21][CH:20]=[CH:19][C:18]=3[N:17]([C:24]3[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=3)[C:16]3[C:11]2=[CH:12][CH:13]=[CH:14][CH:15]=3)=[CH:6][CH:5]=1)[CH3:2].[ClH:34]>O1CCCC1>[CH2:1]([N:3]([CH2:32][CH3:33])[C:4]1[CH:9]=[CH:8][C:7]([C:10]2([Cl:34])[C:23]3[CH:22]=[CH:21][CH:20]=[CH:19][C:18]=3[N:17]([C:24]3[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=3)[C:16]3[C:11]2=[CH:12][CH:13]=[CH:14][CH:15]=3)=[CH:6][CH:5]=1)[CH3:2]

참가 물질

4

반응물 2

HCID 313Hydrochloric AcidHCID 13014081HCID 13014081, 화합물

생성물 1

HCID 934619-Chloro-9-(4-diethylaminophenyl)-10-phenylacridan수율 95.8%

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

9(p-Diethylaminophenyl)-9-methoxy-10-phenylacridan (12.0 g, 0.0276 mole) is slurried in 150 ml of tetrahydrofuran while anhydrous hydrogen chloride is bubbled in with cooling. The hydrogen chloride is bubbled in until the slurry reaches a pH of 1.0 and a bright yellow color is obtained. The product is collected on a Buchner funnel, washed twice with 10 ml portions of tetrahydrofuran and dried at 50° C. to give 11.6 g (95.8% yield) of 9(p-diethylaminophenyl)-9-chloro-10-phenylacridan.

후처리

  1. customis bubbled in
  2. temperaturewith cooling
  3. customThe hydrogen chloride is bubbled in until the slurry
  4. customa bright yellow color is obtained
  5. customThe product is collected on a Buchner funnel
  6. washwashed twice with 10 ml portions of tetrahydrofuran
  7. customdried at 50° C.

출처 및 근거

ORD 기록
ord-41c6b5d04df84e44ab94536377e050ce
출처 데이터셋
uspto-grants-1981_04
특허 번호
US04263398

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