3'-Aminoacetophenone → N-(3-acetylphenyl)hexadecane-1-sulfonamide

HRID 444301

반응식

HRID 444301 반응식
[NH2:1][C:2]1[CH:3]=[C:4]([C:8](=[O:10])[CH3:9])[CH:5]=[CH:6][CH:7]=1.C(N(CC)CC)C.[CH2:18]([S:34](Cl)(=[O:36])=[O:35])[CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][CH2:28][CH2:29][CH2:30][CH2:31][CH2:32][CH3:33]>O1CCCC1>[CH2:18]([S:34]([NH:1][C:2]1[CH:3]=[C:4]([C:8](=[O:10])[CH3:9])[CH:5]=[CH:6][CH:7]=1)(=[O:36])=[O:35])[CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][CH2:28][CH2:29][CH2:30][CH2:31][CH2:32][CH3:33]

참가 물질

5

반응물 3

HCID 74173'-AminoacetophenoneHCID 8471TriethylamineHCID 969231-Hexadecanesulfonyl chloride

생성물 1

HCID 23464850N-(3-acetylphenyl)hexadecane-1-sulfonamide

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

To a mechanically stirred solution of 31.2 g (0.23 M) of m-aminoacetophenone and 35.4 ml (0.254 M) of triethylamine in 1 liter of tetrahydrofuran was added 75 g (0.23 M) of 1-hexadecanesulfonyl chloride at room temperature. The mixture was stirred for 2 hours and the suspended salt was removed. The filtrate was treated on a rotary evaporator to give a solid which was recrystallized from hexane: mp 95.5°-100° C.

후처리

  1. customthe suspended salt was removed
  2. additionThe filtrate was treated on a rotary evaporator
  3. customto give a solid which
  4. customwas recrystallized from hexane

출처 및 근거

ORD 기록
ord-c9d2c608a7bc41c1ada858e58a2807da
출처 데이터셋
uspto-grants-1981_04
특허 번호
US04263393

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