4,5-Dibromo-2-nitroaniline → 4,5-Dibromobenzene-1,2-diamine

HRID 444441노트

반응식

HRID 444441 반응식
[Br:1][C:2]1[CH:3]=[C:4]([C:6]([N+:10]([O-])=O)=[CH:7][C:8]=1[Br:9])[NH2:5]>C(O)C.[Ni]>[Br:1][C:2]1[C:8]([Br:9])=[CH:7][C:6]([NH2:10])=[C:4]([NH2:5])[CH:3]=1

참가 물질

4

반응물 1

HCID 127110274,5-Dibromo-2-nitroaniline

생성물 1

HCID 121969444,5-Dibromobenzene-1,2-diamine

시약·촉매·용매 2

HCID 935Nickel촉매HCID 702Ethanol용매

실험 절차

Following the procedure of Example 9, 5 g. of 3,4-dibromo-6-nitroaniline were reduced in anhydrous ethanol with Raney nickel to yield 4,5-dibromo-o-phenylenediamine which was not isolated but mixed immediately with 2.47 g. of 2-ketoglutaric acid. One hundred ml. of ethanol were added and the mixture heated to refluxing temperature for 3 hours. 3 gms. of β-(6,7-dibromo-3,4-dihydro-3-oxo-2-quinoxaline)propionic acid were obtained melting at 249°-250° C. The free acid was converted to the corresponding ethyl ester by the procedure of Example 8. Ethyl β-(6,7-dibromo-3,4-dihydro-3-oxo-2-quinoxaline)propionate thus prepared melted at 189°-190° C.

출처 및 근거

ORD 기록
ord-7469d21f301142f0a68050d14ebfbf7b
출처 데이터셋
uspto-grants-1981_04
특허 번호
US04264600

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