Lithium Hydroxide → 6-[(4-chlorophenyl)sulfanyl]-3-pyridinylamine

HRID 444462노트

반응식

HRID 444462 반응식
Cl[C:2]1[N:7]=[CH:6][C:5]([N+:8]([O-])=O)=[CH:4][CH:3]=1.[Cl:11][C:12]1[CH:17]=[CH:16][C:15]([SH:18])=[CH:14][CH:13]=1.[OH-].[Li+]>CN(C=O)C>[Cl:11][C:12]1[CH:17]=[CH:16][C:15]([S:18][C:2]2[N:7]=[CH:6][C:5]([NH2:8])=[CH:4][CH:3]=2)=[CH:14][CH:13]=1

참가 물질

5

반응물 3

HCID 3939Lithium HydroxideHCID 7815p-ChlorothiophenolHCID 783082-Chloro-5-nitropyridine

생성물 1

HCID 28001276-[(4-chlorophenyl)sulfanyl]-3-pyridinylamine

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

6-Chloro-3-nitropyridine (54.5 grams), 4-chlorothiophenol (50.0 grams), and lithium hydroxide (12.5 grams) were mixed in about 500 ml. of DMF and stirred overnight (about 18 hours) at room temperature. The reaction mixture was poured into ice-water, filtered, and the separated product washed three times with water and air dried, yield, 100 grams.

후처리

  1. filtrationfiltered
  2. washthe separated product washed three times with water and air
  3. customdried
  4. customyield

출처 및 근거

ORD 기록
ord-f815efe19f0e4996899da64acd82ac39
출처 데이터셋
uspto-grants-1981_04
특허 번호
US04264605

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