Sodium Hydroxide → HCID 178525591, 화합물

HRID 444553노트

반응식

HRID 444553 반응식
C([O:8][C:9]([CH2:11][CH2:12][N:13]1[C:17]([SH:18])=[N:16][N:15]=[N:14]1)=[O:10])C1C=CC=CC=1.[OH-].[Na+]>O1CCCC1>[C:9]([CH2:11][CH2:12][N:13]1[C:17]([SH:18])=[N:16][N:15]=[N:14]1)([OH:10])=[O:8]

참가 물질

4

반응물 2

HCID 14798Sodium HydroxideHCID 178520826HCID 178520826, 화합물

생성물 1

HCID 178525591HCID 178525591, 화합물수율 75.1%

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

A mixture of 3.84 g of 1-(2-benzyloxycarbonylethyl)-1H-tetrazole-5-thiol, 30 ml of tetrahydrofuran and 29 ml of 1 N-sodium hydroxide was allowed to stand at room temperature for 2 hours. The reaction mixture was washed with ethyl acetate and the water layer was adjusted to pH 1 with 10% hydrochloric acid and extracted with ethyl acetate. The extract was washed with an aqueous solution of sodium chloride, dried and concentrated to dryness. By the above procedure there were obtained 1.9 g of powder of the captioned compound.

후처리

  1. washThe reaction mixture was washed with ethyl acetate
  2. extractionextracted with ethyl acetate
  3. washThe extract was washed with an aqueous solution of sodium chloride
  4. customdried
  5. concentrationconcentrated to dryness

출처 및 근거

ORD 기록
ord-2d02a35dc9c540f8955264a48157a394
출처 데이터셋
uspto-grants-1981_04
특허 번호
US04264595

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