Hydrochloric Acid → 4-Amino-2-[(2-aminoethyl)amino]-1,3-thiazol-5-carbonitrile dihydrochloride
반응식
[NH2:1][C:2]1[N:3]=[C:4]([NH:9][CH2:10][CH2:11][NH:12]C(=O)OC(C)(C)C)[S:5][C:6]=1[C:7]#[N:8].[ClH:20]>O1CCOCC1>[ClH:20].[ClH:20].[NH2:1][C:2]1[N:3]=[C:4]([NH:9][CH2:10][CH2:11][NH2:12])[S:5][C:6]=1[C:7]#[N:8]참가 물질
4
실험 절차
2.18 g (7.7 mmol) of tert-butyl {2-[(4-amino-5-cyano-1,3-thiazol-2-yl)amino]ethyl}carbamate (Example 7A) in 100 ml of 4N hydrogen chloride in dioxane were stirred at RT for 30 min. The reaction mixture was concentrated. This gave 2 g (100% of theory) of the product as a solid.
후처리
- concentrationThe reaction mixture was concentrated
출처 및 근거
- ORD 기록
- ord-ca49544492a7441a99817ff0cd67e739
- 출처 데이터셋
- uspto-grants-2013_07
- 특허 번호
- US08476267B2
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