Hydrochloric Acid → 1-[4-Amino-2-(piperidin-3-ylamino)-1,3-thiazol-5-yl]ethanone dihydrochloride
반응식
[C:1]([C:4]1[S:8][C:7]([NH:9][CH:10]2[CH2:15][CH2:14][CH2:13][N:12](C(OC(C)(C)C)=O)[CH2:11]2)=[N:6][C:5]=1[NH2:23])(=[O:3])[CH3:2].[ClH:24]>O1CCOCC1>[ClH:24].[ClH:24].[NH2:23][C:5]1[N:6]=[C:7]([NH:9][CH:10]2[CH2:15][CH2:14][CH2:13][NH:12][CH2:11]2)[S:8][C:4]=1[C:1](=[O:3])[CH3:2]참가 물질
4
실험 절차
Analogously to the preparation of Example 38A, 160 mg (0.15 mmol) of tert-butyl 3-[(5-acetyl-4-amino-1,3-thiazol-2-yl)amino]piperidine-1-carboxylate (Example 49A) and 20 ml of hydrochloric acid in dioxane (4M) gave 40 mg (87% of theory) of the product as a solid.
출처 및 근거
- ORD 기록
- ord-64af07fc22154919b32a396e5957034f
- 출처 데이터셋
- uspto-grants-2013_07
- 특허 번호
- US08476267B2
반응 노트
불러오는 중…