(4-Isopropyl-phenyl)-(5-methoxy-2-nitro-phenyl)-methanone → (2-Amino-5-methoxy-phenyl)-(4-isopropyl-phenyl)-methanone

HRID 445152노트

반응식

HRID 445152 반응식
[CH:1]([C:4]1[CH:9]=[CH:8][C:7]([C:10]([C:12]2[CH:17]=[C:16]([O:18][CH3:19])[CH:15]=[CH:14][C:13]=2[N+:20]([O-])=O)=[O:11])=[CH:6][CH:5]=1)([CH3:3])[CH3:2]>CO.[Ni]>[NH2:20][C:13]1[CH:14]=[CH:15][C:16]([O:18][CH3:19])=[CH:17][C:12]=1[C:10]([C:7]1[CH:8]=[CH:9][C:4]([CH:1]([CH3:3])[CH3:2])=[CH:5][CH:6]=1)=[O:11]

참가 물질

4

반응물 1

HCID 45140002(4-Isopropyl-phenyl)-(5-methoxy-2-nitro-phenyl)-methanone

생성물 1

HCID 45139626(2-Amino-5-methoxy-phenyl)-(4-isopropyl-phenyl)-methanone

시약·촉매·용매 2

HCID 935Nickel촉매HCID 887Methanol용매

실험 절차

A solution of 5.6 g (18.7 mmol) (4-isopropyl-phenyl)-(5-methoxy-2-nitro-phenyl)-methanone in 100 ml methanol is hydrogenated in the presence of 2 g Raney nickel at 5 bar for 5 h. The reaction mixture is filtered and the filtrate is evaporated. The residue is dissolved in ether and the product is precipitated by the addition of gaseous hydrochloric acid as its hydrochloride.

후처리

  1. filtrationThe reaction mixture is filtered
  2. customthe filtrate is evaporated
  3. dissolutionThe residue is dissolved in ether
  4. customthe product is precipitated by the addition of gaseous hydrochloric acid as its hydrochloride

출처 및 근거

ORD 기록
ord-d122323607074917822bc541d808a9b9
출처 데이터셋
uspto-grants-2013_07
특허 번호
US08476286B2

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