Hydrochloric Acid → HCID 68496449, 화합물

HRID 445245

반응식

HRID 445245 반응식
C([N:8]1[CH:17]([CH3:18])[CH2:16][C:15]2[C:10](=[CH:11][CH:12]=[CH:13][CH:14]=2)[CH:9]1[C:19]1[CH:24]=[CH:23][C:22]([C:25]([F:28])([F:27])[F:26])=[CH:21][CH:20]=1)C1C=CC=CC=1.[ClH:29]>CO.[Pd]>[ClH:29].[CH3:18][CH:17]1[CH2:16][C:15]2[C:10](=[CH:11][CH:12]=[CH:13][CH:14]=2)[CH:9]([C:19]2[CH:20]=[CH:21][C:22]([C:25]([F:27])([F:26])[F:28])=[CH:23][CH:24]=2)[NH:8]1

참가 물질

5

반응물 2

HCID 313Hydrochloric AcidHCID 595362822-Benzyl-3-methyl-1-(4-(trifluoromethyl)phenyl)-1,2,3,4-tetrahydroisoquinoline

생성물 1

HCID 68496449HCID 68496449, 화합물

시약·촉매·용매 2

HCID 23938Palladium촉매2회HCID 887Methanol용매

실험 절차

To a solution of 2-benzyl-3-methyl-1-(4-(trifluoromethyl)phenyl)-1,2,3,4-tetrahydroisoquinoline (485 mg, 1.27 mmol) in MeOH (5 mL) was added palladium, 10 wt. % on activated carbon (41 mg, 0.38 mmol). The resulting mixture was then stirred under H2 for 16 h. Then, 5 N HCl (0.2 mL) was added followed by palladium, 10 wt. % on activated carbon (41 mg, 0.38 mmol). The resulting mixture was stirred at RT under H2 (45 psi) for 30 min. The mixture was filtered through celite and the celite was washed with MeOH (2×5 mL). The combined filtrates were concentrated to give the title compound as a light yellow solid (HCl salt), which was used in the next step without further purification.

후처리

  1. stirringThe resulting mixture was stirred at RT under H2 (45 psi) for 30 min
  2. filtrationThe mixture was filtered through celite
  3. washthe celite was washed with MeOH (2×5 mL)
  4. concentrationThe combined filtrates were concentrated

출처 및 근거

ORD 기록
ord-8b290a7c96fc4c3ba073afaa60c6d4c6
출처 데이터셋
uspto-grants-2013_07
특허 번호
US08476297B2

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