Methanol → HCID 59536363, 화합물

HRID 445303노트

반응식

HRID 445303 반응식
Cl.[F:2][C:3]1([F:10])[CH2:8][CH2:7][CH:6]([NH2:9])[CH2:5][CH2:4]1.Cl[C:12]([O:14][C:15]1[CH:20]=[CH:19][C:18]([N+:21]([O-:23])=[O:22])=[CH:17][CH:16]=1)=[O:13].CCN(C(C)C)C(C)C.CO>C(Cl)Cl>[F:2][C:3]1([F:10])[CH2:8][CH2:7][CH:6]([NH:9][C:12](=[O:13])[O:14][C:15]2[CH:16]=[CH:17][C:18]([N+:21]([O-:23])=[O:22])=[CH:19][CH:20]=2)[CH2:5][CH2:4]1

참가 물질

6

반응물 4

HCID 887MethanolHCID 81531DiisopropylethylamineHCID 821294-Nitrophenyl chloroformateHCID 231506694,4-Difluorocyclohexan-1-amine hydrochloride

생성물 1

HCID 59536363HCID 59536363, 화합물

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

To a solution of 4,4-difluorocyclohexanamine hydrochloride (Matrix scientific, 250 mg, 1.45 mmol) in DCM (5 mL) was added 4-nitrophenyl chloroformate (367 mg, 1.82 mmol) and DIEA (507 μl, 0.29 mmol). The resulting mixture was then stirred at RT for 16 h. Then, MeOH (2 mL) was added and the solvents were removed. The residue was purified by silica gel flash column chromatography (0%-100% EtOAc/hexane) to give the title compound as a yellow solid.

후처리

  1. customthe solvents were removed
  2. customThe residue was purified by silica gel flash column chromatography (0%-100% EtOAc/hexane)

출처 및 근거

ORD 기록
ord-00c2f84f8c2b42dca18083329f211cb5
출처 데이터셋
uspto-grants-2013_07
특허 번호
US08476297B2

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