Hydrochloric Acid → (5-(4-((3-Fluorobenzyl)oxy)phenyl)-1,3,4-thiadiazol-2-yl)methanamine

HRID 445400노트

반응식

HRID 445400 반응식
[F:1][C:2]1[CH:3]=[C:4]([CH:27]=[CH:28][CH:29]=1)[CH2:5][O:6][C:7]1[CH:12]=[CH:11][C:10]([C:13]2[S:17][C:16]([CH2:18][NH:19]C(=O)OC(C)(C)C)=[N:15][N:14]=2)=[CH:9][CH:8]=1.Cl>O1CCOCC1>[F:1][C:2]1[CH:3]=[C:4]([CH:27]=[CH:28][CH:29]=1)[CH2:5][O:6][C:7]1[CH:8]=[CH:9][C:10]([C:13]2[S:17][C:16]([CH2:18][NH2:19])=[N:15][N:14]=2)=[CH:11][CH:12]=1

참가 물질

4

반응물 2

HCID 313Hydrochloric AcidHCID 86663647Tert-butyl ((5-(4-((3-fluorobenzyl)oxy)phenyl)-1,3,4-thiadiazol-2-yl)methyl)carbamate

생성물 1

HCID 66822259(5-(4-((3-Fluorobenzyl)oxy)phenyl)-1,3,4-thiadiazol-2-yl)methanamine

시약·촉매·용매 1

HCID 312751,4-Dioxane용매2회

실험 절차

A solution of tert-butyl ((5-(4-((3-fluorobenzyl)oxy)phenyl)-1,3,4-thiadiazol-2-yl)methyl)carbamate, dioxane (16 mL), and 4N HCl in dioxane (13 ml) was stirred at room temperature for 4 h. The resulting mixture was concentrated in vacuo to yield (5-(4-((3-fluorobenzyl)oxy)phenyl)-1,3,4-thiadiazol-2-yl)methanamine, which was in the next step used directly without further purification. MS (ES+) 316 (MH+).

후처리

  1. concentrationThe resulting mixture was concentrated in vacuo

출처 및 근거

ORD 기록
ord-5b2065333ed841d9b6ca7dc754d27e70
출처 데이터셋
uspto-grants-2013_07
특허 번호
US08476302B2

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