Methanol → HCID 59619635, 화합물

HRID 445653노트

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HRID 445653 반응식
[Na].Cl[C:3]1[C:8]([O:9][CH:10]([CH3:12])[CH3:11])=[CH:7][CH:6]=[CH:5][N:4]=1.[CH3:13][OH:14]>>[CH:10]([O:9][C:8]1[C:3]([O:14][CH3:13])=[N:4][CH:5]=[CH:6][CH:7]=1)([CH3:12])[CH3:11]

참가 물질

4

반응물 3

HCID 887Methanol2회HCID 5360545SodiumHCID 336790892-Chloro-3-[(propan-2-yl)oxy]pyridine

생성물 1

HCID 59619635HCID 59619635, 화합물

반응 조건

온도
150 °C

실험 절차

To a solution of methanolate obtained by dissolving sodium (534 mg, 23.25 mmol) in MeOH (8 ml) was added a solution of 2-chloro-3-isopropoxy-pyridine (Stage 93.1.4, 1.14 g, 6.64 mmol) in MeOH (2 ml). The reaction mixture was heated at 150° C. by microwave irradiation for 25 min then concentrated and quenched with EtOAc and brine. The organic layer was dried over Na2SO4, filtered and evaporated to give the title compound as an oil (HPLC: tR 2.66 min (Method A); M+H=264 MS-ES)

후처리

  1. concentrationthen concentrated
  2. customquenched with EtOAc and brine
  3. dry with materialThe organic layer was dried over Na2SO4
  4. filtrationfiltered
  5. customevaporated

출처 및 근거

ORD 기록
ord-53667973c7e14d1eab3e41913cde97bb
출처 데이터셋
uspto-grants-2013_07
특허 번호
US08476294B2

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