Ethyl benzoylformate → 1-[2-(Benzylthio)-8-oxo-5,6,7,8-tetrahydroquinazolin-7-yl]-2-phenylethane-1,2-dione

HRID 44615

반응식

HRID 44615 반응식
[CH2:1]([S:8][C:9]1[N:18]=[CH:17][C:16]2[CH2:15][CH2:14][CH2:13][C:12](=[O:19])[C:11]=2[N:10]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[H-].[Na+].[O:22]=[C:23]([C:29]1[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=1)[C:24](OCC)=[O:25]>O1CCCC1>[CH2:1]([S:8][C:9]1[N:18]=[CH:17][C:16]2[CH2:15][CH2:14][CH:13]([C:24](=[O:25])[C:23]([C:29]3[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=3)=[O:22])[C:12](=[O:19])[C:11]=2[N:10]=1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

참가 물질

5

반응물 3

HCID 15349Ethyl benzoylformateHCID 24758Sodium hydrideHCID 574441132-(benzylthio)-6,7-dihydroquinazolin-8(5H)-one

생성물 1

HCID 574441141-[2-(Benzylthio)-8-oxo-5,6,7,8-tetrahydroquinazolin-7-yl]-2-phenylethane-1,2-dione수율 68%

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

To a solution of 0.22 g (0.81 mmol) of 2-(benzylthio)-6,7-dihydroquinazolin-8(5H)-one in 5 mL of dry tetrahydrofuran cooled to −50° C., 0.10 g of sodium hydride 60% in mineral oil were added. The resulting suspension was maintained at the same temperature for 30 minutes and then 0.59 mL of ethyl α-oxobenzeneacetate (PhCOCOOEt) were added and the reaction mixture allowed to come to room temperature. After 16 hours the mixture was partitioned between water and ethyl acetate and the organic layer was dried over Na2SO4 and evaporated to dryness. The residue was purified by chromatography on a silica gel column (eluant hexane/ethyl acetate 7/3) giving 0.22 g (68% yield) of the title compound.

후처리

  1. temperatureThe resulting suspension was maintained at the same temperature for 30 minutes
  2. customto come to room temperature
  3. customAfter 16 hours the mixture was partitioned between water and ethyl acetate
  4. dry with materialthe organic layer was dried over Na2SO4
  5. customevaporated to dryness
  6. customThe residue was purified by chromatography on a silica gel column (eluant hexane/ethyl acetate 7/3)

출처 및 근거

ORD 기록
ord-6cb9fd63185241d28ffc6683e788d26e
출처 데이터셋
uspto-grants-2013_09
특허 번호
US08541429B2

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