Hydrochloric Acid → 4-Amino-N-(1,1-dimethylethyl)benzenesulfonamide

HRID 446155노트

반응식

HRID 446155 반응식
C([NH:4][C:5]1[CH:10]=[CH:9][C:8]([S:11]([NH:14][C:15]([CH3:18])([CH3:17])[CH3:16])(=[O:13])=[O:12])=[CH:7][CH:6]=1)(=O)C.[OH-].[K+].Cl>O.CO>[NH2:4][C:5]1[CH:10]=[CH:9][C:8]([S:11]([NH:14][C:15]([CH3:18])([CH3:17])[CH3:16])(=[O:13])=[O:12])=[CH:7][CH:6]=1

참가 물질

6

반응물 3

HCID 313Hydrochloric AcidHCID 14797Potassium HydroxideHCID 668309N-[4-(tert-butylsulfamoyl)phenyl]acetamide

생성물 1

HCID 8326274-Amino-N-(1,1-dimethylethyl)benzenesulfonamide수율 89%

시약·촉매·용매 2

HCID 887Methanol용매HCID 962Water용매3회

실험 절차

A solution of 4-acetylamino-N-tert-butylbenzenesulfonamide (8.0 g, 29.6 mmol), KOH (8.30 g, 148 mmol), H2O (6 mL) and MeOH (24 mL) is heated at 100° C. for 2 h. H2O (24 mL) is added and the mixture is heated for two more hours. It is allowed to cool, H2O is added and it is brought to pH 8 with 1N HCl. It is then extracted with EtOAc, dried over Na2SO4 and the solvent is removed, to give 6.0 g of the product as a white solid (yield: 89%).

후처리

  1. temperaturethe mixture is heated for two more hours
  2. temperatureto cool
  3. extractionIt is then extracted with EtOAc
  4. dry with materialdried over Na2SO4
  5. customthe solvent is removed

출처 및 근거

ORD 기록
ord-7accfb88a5a149a0a2568fbd23b95b7d
출처 데이터셋
uspto-grants-2013_07
특허 번호
US08476456B2

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