Methyl iodide → HCID 58396979, 화합물
반응식
[NH2:1][C:2]1[CH:7]=[C:6]([C:8]([CH2:11][CH3:12])([CH3:10])[CH3:9])[CH:5]=[CH:4][C:3]=1[OH:13].[C:14](=O)([O-])[O-].[K+].[K+].CI>CN(C=O)C.CCOC(C)=O>[CH3:14][NH:1][C:2]1[CH:7]=[C:6]([C:8]([CH2:11][CH3:12])([CH3:9])[CH3:10])[CH:5]=[CH:4][C:3]=1[OH:13]참가 물질
6
실험 절차
2-Amino-4-tert-pentylphenol (5.00 g, 27.8 mmol) and potassium carbonate (3.88 g, 28.1 mmol) were mixed at RT for 2.5 hours in DMF (15 mL). Methyl iodide (1.20 mL, 19.3 mmol) was added and the mixture was stirred overnight at RT. Diluted the mixture with EtOAc and extracted with aqueous sodium bicarbonate and water. Dried the organic layers over sodium sulfate, filtered, concentrated and purified by silica gel chromatography (10-15% MTBE/hexanes). Concentrated the product fractions to yield the title compound.
후처리
- extractionextracted with aqueous sodium bicarbonate and water
- dry with materialDried the organic layers over sodium sulfate
- filtrationfiltered
- concentrationconcentrated
- custompurified by silica gel chromatography (10-15% MTBE/hexanes)
- concentrationConcentrated the product fractions
출처 및 근거
- ORD 기록
- ord-298b0fbe0a004ee59bbbeaef43e84fc4
- 출처 데이터셋
- uspto-grants-2013_07
- 특허 번호
- US08476434B2
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